Argonaute proteins degrade specific invader nucleic acids in eukaryotic and prokaryotic innate immunity. Here, Kanevskaya et al. describe a bacterial immune system in which RNA-guided recognition of invader DNA by Argonaute triggers formation of HNH nuclease filaments with collateral activity, protecting the bacterial population from invaders.
- Anna Kanevskaya
- Manju Narwal
- Andrey Kulbachinskiy
