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SurfDock is a surface-informed diffusion generative model for reliable and accurate protein–ligand complex prediction

SurfDock is a method for predicting protein–ligand complex structures by leveraging multimodal protein information and generative diffusion frameworks. Its results can be generalized to unseen proteins and real-world settings.

Duanhua Cao
Mingan Chen
Mingyue Zheng
Research27 Nov 2024
Nature Methods

Volume: 22, P: 310-322
Modular synthesis of clickable peptides via late-stage maleimidation on C(7)-H tryptophan

Cyclic peptides are of interest due to their application in pharmaceutical industry, but currently there are limited methodologies for their synthesis. Here, the authors report an efficient and direct peptide cyclization via rhodium(III)-catalysed C(7)-H maleimidation.

Peng Wang
Jiang Liu
Yuguo Zheng
ResearchOpen Access05 Jul 2023
Nature Communications

Volume: 14, P: 1-14
Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase

Although general inhibitors of the ubiquitin-proteasome system have been reported, compounds targeting specific ubiquitylation enzymes should be beneficial in clinical applications and basic research. Aghajan et al. present an inhibitor of the yeast SCF^Met30 E3 ligase that prevents the binding of the Met30 F-box protein to the core ligase complex.

Mariam Aghajan
Nao Jonai
Jing Huang
Research27 Jun 2010
Nature Biotechnology

Volume: 28, P: 738-742
USP22 upregulates ZEB1-mediated VEGFA transcription in hepatocellular carcinoma

Kai Zeng
Weiwen Xie
Yue Zhao
ResearchOpen Access11 Mar 2023
Cell Death & Disease

Volume: 14, P: 1-15

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SurfDock is a surface-informed diffusion generative model for reliable and accurate protein–ligand complex prediction

Modular synthesis of clickable peptides via late-stage maleimidation on C(7)-H tryptophan

Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase

USP22 upregulates ZEB1-mediated VEGFA transcription in hepatocellular carcinoma

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