Phenotype switching is a key driver of melanoma progression and therapy resistance. Here, the authors identify the small MAF family transcription factor MAFG as a critical regulator of microphthalmia-associated transcription factor (MITF) activity and melanoma cell state plasticity through binding MITF to redirect its genomic occupancy and modulate its transcriptional programming.
- Olga Vera
- Michael Martinez
- Florian A. Karreth
