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Integrin β1 controls VE-cadherin localization and blood vessel stability

The role of integrin β1 in angiogenesis is poorly understood. Here, the authors show that integrin β1 regulates murine angiogenesis and adherens junction integrity by controlling VE-cadherin localization, myosin light chain phosphorylation and the function of the Rap1/MRCK and Rho/Rho-kinase pathways.

Hiroyuki Yamamoto
Manuel Ehling
Ralf H. Adams
Research10 Mar 2015
Nature Communications

Volume: 6, P: 1-14
Neuropilin 1 and its inhibitory ligand mini-tryptophanyl-tRNA synthetase inversely regulate VE-cadherin turnover and vascular permeability

Functional vascular tree formation is a key step in many contexts, such as cancer, and Neuropilin1 (NRP1) has been associated with adhesion receptor endocytic turnover. Here, authors show NRP1 and its mini-WARS ligand play a role in reducing endothelial permeability.

Noemi Gioelli
Lisa J. Neilson
Guido Serini
ResearchOpen Access20 Jul 2022
Nature Communications

Volume: 13, P: 1-16
Dll4 and Notch signalling couples sprouting angiogenesis and artery formation

Pitulescu et al. and Hasan et al. show that Dll4–Notch signalling in endothelial tip cells regulates angiogenesis through control of artery formation, linking sprouting angiogenesis and artery formation.

Mara E. Pitulescu
Inga Schmidt
Ralf H. Adams
Research17 Jul 2017
Nature Cell Biology

Volume: 19, P: 915-927
Polarized actin and VE-cadherin dynamics regulate junctional remodelling and cell migration during sprouting angiogenesis

The formation of new blood vessels requires both polarized cell migration and coordinated control of endothelial cell contacts. Here, Cao and colleagues describe at the sub-cellular level the cytoskeletal and cell junction dynamics regulating these processes upon VEGF-induced cell elongation.

Jiahui Cao
Manuel Ehling
Hans Schnittler
ResearchOpen Access20 Dec 2017
Nature Communications

Volume: 8, P: 1-20

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Integrin β1 controls VE-cadherin localization and blood vessel stability

Neuropilin 1 and its inhibitory ligand mini-tryptophanyl-tRNA synthetase inversely regulate VE-cadherin turnover and vascular permeability

Dll4 and Notch signalling couples sprouting angiogenesis and artery formation

Polarized actin and VE-cadherin dynamics regulate junctional remodelling and cell migration during sprouting angiogenesis

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