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Showing 1–3 of 3 results
Advanced filters: Author: Manuel Hörl Clear advanced filters

  • Bacteria must adapt their metabolism in the face of dynamically changing nutrient availability. Here, using their constraint-based modeling approach the authors analyze E. coli exometabolome data during growth in complex medium, revealing temporal coordination of glucose and amino acid catabolism.

    • Mattia Zampieri
    • Manuel Hörl
    • Uwe Sauer
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • Myocardial hypoxia activates HIF1α, which activates the splicing factor SF3B1, which mediates a splice switch of the fructose-metabolising enzyme KHK, so that the C isoform that has superior affinity for fructose is expressed in the heart—pathological heart growth and contractile dysfunction can therefore be suppressed by depleting SF3B1 or deleting KHK.

    • Peter Mirtschink
    • Jaya Krishnan
    • Wilhelm Krek
    Research
    Nature
    Volume: 522, P: 444-449