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Showing 1–2 of 2 results
Advanced filters: Author: Manuel Leonardo Merz Clear advanced filters

  • When 100 social and behavioural science claims were examined, 34% of reanalyses closely matched the original results, with 74% reaching the same conclusion, revealing limited robustness of single-path analyses and the need to address analytical uncertainty.

    • Balazs Aczel
    • Barnabas Szaszi
    • Brian A. Nosek
    Research
    Nature
    Volume: 652, P: 135-142

  • Macrocycles have potential as therapeutics, but their libraries are currently not large enough for high-throughput screening. Here, the authors show a combinatorial approach to generate a library of almost 20’000 macrocycles by conjugating carboxylic-acid fragments to macrocyclic scaffolds, identifying nanomolar inhibitors against thrombin and binders of MDM2.

    • Sevan Habeshian
    • Manuel Leonardo Merz
    • Christian Heinis
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14