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Showing 1–7 of 7 results
Advanced filters: Author: Manuel Stucki Clear advanced filters

  • DNA damage induces silencing of ribosomal RNA (rRNA) transcription. Stucki and colleagues reveal that rRNA silencing is an ATM-dependent pan-nuclear response to irradiation, in which the nucleolar protein Treacle targets DNA-damage protein NBS1 to nucleoli.

    • Dorthe H. Larsen
    • Flurina Hari
    • Manuel Stucki
    Research
    Nature Cell Biology
    Volume: 16, P: 792-803

  • DNA double-strand breaks in ribosomal DNA repeats is associated with repression of ribosomal RNA synthesis. Here the authors reveal a cooperation between TOPBP1 and Treacle in the signaling cascade that triggers transcriptional inhibition and nucleolar segregation in response to rDNA breaks.

    • Clémence Mooser
    • Ioanna-Eleni Symeonidou
    • Manuel Stucki
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • In this work, CIP2A is discovered as a TOPBP1-interacting protein that regulates TOPBP1 localization specifically in mitosis. Cells lacking CIP2A display increased radio-sensitivity, micronuclei formation and chromosomal instability.

    • Mara De Marco Zompit
    • Mònica Torres Esteban
    • Manuel Stucki
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • Polyamines prevent the action of kinases on acidic phosphorylatable motifs in spliceosomal proteins, thus providing a mechanism for metabolite-mediated regulation of alternative splicing in cells.

    • Amaia Zabala-Letona
    • Mikel Pujana-Vaquerizo
    • Arkaitz Carracedo
    ResearchOpen Access
    Nature
    Volume: 651, P: 819-828

  • How do cells track down the occasional lesion among the billons of base pairs of chromosomal DNA? A surprising discovery unravels a potential new mechanism: the Tudor domains of the DNA-damage response factor 53BP1 interact with methylated histones that are likely to become exposed during local chromatin relaxation at sites of DNA double-strand breaks.

    • Manuel Stucki
    • Stephen P. Jackson
    News & Views
    Nature Cell Biology
    Volume: 6, P: 1150-1152