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Optimized inhaled LNP formulation for enhanced treatment of idiopathic pulmonary fibrosis via mRNA-mediated antibody therapy

Inhaled lipid nanoparticles face several challenges when delivered to the lungs. Here, the authors show “LOOP”-optimized iLNP-HP08^LOOP could withstand shear damage generated during nebulization process and be used to develop mRNA-mediated antibody therapy for treating idiopathic pulmonary fibrosis.

Xin Bai
Qijing Chen
Xue-Qing Zhang
ResearchOpen Access10 Aug 2024
Nature Communications

Volume: 15, P: 1-18
mRNA lipid nanoparticle-mediated pyroptosis sensitizes immunologically cold tumors to checkpoint immunotherapy

mRNA nanomedicine-based gene therapy may offer opportunities for cancer treatment. Here the authors show that mRNA lipid nanoparticles encoding the N-terminal domain of gasdermin B trigger pyroptosis and promote anti-tumor immune responses in preclinical cancer models.

Fengqiao Li
Xue-Qing Zhang
Xiaoyang Xu
ResearchOpen Access15 Jul 2023
Nature Communications

Volume: 14, P: 1-16
A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology

Neuron types vulnerable to tau accumulation (excitatory neurons) in AD brain are intrinsically less able to maintain tau homeostasis than neuron types that are resistant (inhibitory neurons).

Hongjun Fu
Andrea Possenti
Karen E. Duff
Research17 Dec 2018
Nature Neuroscience

Volume: 22, P: 47-56

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