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Showing 1–12 of 12 results
Advanced filters: Author: María Mittelbrunn Clear advanced filters

  • Cells secrete micro-RNAs by packaging them into exosomes; however, the mechanisms by which this packaging occurs are unclear. Here, the authors identify a sequence motif that confers exosomal targeting to micro-RNAs and identify a ribonucleoprotein complex that plays a role in this process.

    • Carolina Villarroya-Beltri
    • Cristina Gutiérrez-Vázquez
    • Francisco Sánchez-Madrid
    ResearchOpen Access
    Nature Communications
    Volume: 4, P: 1-10

  • Exosomes released from cells can transfer RNA to recipient cells. In this study, the authors demonstrate that microRNAs in exosomes from T cells can be transferred to antigen-presenting cells during immune synapsis, and that this can alter gene expression, suggesting a new form of cellular communication.

    • María Mittelbrunn
    • Cristina Gutiérrez-Vázquez
    • Francisco Sánchez-Madrid
    ResearchOpen Access
    Nature Communications
    Volume: 2, P: 1-10

  • Hypertrophic cardiomyopathy (HCM) is a major cause of sudden cardiac death in young adults. Here, the authors show that mutations in a sarcomeric protein filamin C contribute to the development of familial HCM and are associated with an increased incidence of sudden cardiac death.

    • Rafael Valdés-Mas
    • Ana Gutiérrez-Fernández
    • Carlos López-Otín
    Research
    Nature Communications
    Volume: 5, P: 1-9

  • T cells undergo age-related changes that impair their organismal functions. Here Soto-Heredero et al. show that regulatory T cells characterized by the expression of KLRG1 accumulate with age in both mice and humans and exhibit features including mitochondrial decline and an inflammatory phenotype.

    • Gonzalo Soto-Heredero
    • Enrique Gabandé-Rodríguez
    • María Mittelbrunn
    ResearchOpen Access
    Nature Aging
    Volume: 5, P: 799-815

  • The mysteries behind immune aging and its related inflammation are being unmasked. Jin et al. reveal that the defective turnover of damaged mitochondria in CD4+ T cells from older individuals results in the exacerbated secretion of mitochondrial DNA, which fuels inflammaging and impairs immune responses.

    • Manuel M. Gómez de las Heras
    • María Mittelbrunn
    News & Views
    Nature Aging
    Volume: 3, P: 475-476

  • Multivesicular bodies (MVB) are endosomal compartments that can either fuse with the plasma membrane for the secretion of exosomes, or fuse with the lysosome and be degraded along with their contents. Here, the authors show that ISGylation of the MVB protein TSG101 impairs exosome secretion and acts as a regulator of MVB fate.

    • Carolina Villarroya-Beltri
    • Francesc Baixauli
    • Francisco Sánchez-Madrid
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-11

  • T cells are activated by antigen-bearing dendritic cells (DC), but how DCs receive reciprocal activating signals from T cells is still unclear. Here the authors show that mitochondrial DNA-containing extracellular vesicles from activated T cells can prime DCs for anti-viral immunity via the cGAS/STING DNA sensing pathways.

    • Daniel Torralba
    • Francesc Baixauli
    • Francisco Sánchez-Madrid
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-17

  • In this Roadmap, Stellos and colleagues discuss the mechanisms of cardiovascular system ageing and how the ageing of blood, vessels and heart relates to the decline in organ function, and highlight potential therapeutic interventions, challenges in ageing research and future directions for preclinical and clinical studies.

    • Luca Liberale
    • Simon Tual-Chalot
    • Konstantinos Stellos
    Reviews
    Nature Reviews Cardiology
    Volume: 22, P: 577-605

  • The authors uncover a role for the proteostasis modulator AIRAPL as a tumor suppressor in myeloproliferative malignancies, through its regulation of IGFR stability. The results ascribe a biological function to AIRAPL, and they implicate prosteostatic deregulation as an oncogenic mechanism in myeloid transformation, thus suggesting potential novel therapeutic strategies.

    • Fernando G Osorio
    • Clara Soria-Valles
    • Carlos López-Otín
    Research
    Nature Medicine
    Volume: 22, P: 91-96

  • Fecal microbiome transplantation or probiotic therapy with Akkermansia muciniphila extends the lifespan and improves the health status of progeroid mice, pointing to the importance of the gut microbiome in regulating lifespan and healthspan.

    • Clea Bárcena
    • Rafael Valdés-Mas
    • Carlos López-Otín
    Research
    Nature Medicine
    Volume: 25, P: 1234-1242