Nature Search

Apoptosis and melanoma chemoresistance

María S Soengas
Scott W Lowe
Reviews19 May 2003
Oncogene

Volume: 22, P: 3138-3151
The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2

Chaib et al. find that therapy-induced senescent cells have high programmed cell death 1 ligand 2 (PD-L2), contributing to recurrence. They show that PD-L2 blocking combined with chemotherapy is therapeutically beneficial because it reduces senescent cells and immunosuppressive cell recruitment.

Selim Chaib
José Alberto López-Domínguez
Manuel Serrano
ResearchOpen Access24 Jan 2024
Nature Cancer

Volume: 5, P: 448-462
Repriming of DNA synthesis at stalled replication forks by human PrimPol

DNA damage that causes replication forks to stall can be bypassed via translesion synthesis (TLS). New work has identified a bifunctional human primase and TLS polymerase, PrimPol, that reinitiates DNA synthesis beyond the damage site by virtue of its unique primase activity, revealing a novel pathway of DNA-damage tolerance.

Silvana Mourón
Sara Rodriguez-Acebes
Juan Méndez
Research17 Nov 2013
Nature Structural & Molecular Biology

Volume: 20, P: 1383-1389
Cell position matters in tumour development

Skin cells called melanocytes are not equally affected by the same genetic changes. Their ability to form tumours has now been linked to gene-expression programs that are selectively activated according to a cell’s anatomical position.

Jean-Christophe Marine
María S. Soengas
News & Views30 Mar 2022
Nature

Volume: 604, P: 248-250
Systemic rewiring of dendritic cells by melanoma-secreted midkine impairs immune surveillance and response to immune checkpoint blockade

Catena et al. report that melanoma-secreted midkine impairs differentiation and function of dendritic cells, limiting antitumor immunity and response to immune checkpoint blockade.

Xavier Catena
Marta Contreras-Alcalde
María S. Soengas
Research28 Mar 2025
Nature Cancer

Volume: 6, P: 682-701
Inactivation of the apoptosis effector Apaf-1 in malignant melanoma

María S. Soengas
Paola Capodieci
Scott W. Lowe
Research11 Jan 2001
Nature

Volume: 409, P: 207-211
Lineage-specific roles of the cytoplasmic polyadenylation factor CPEB4 in the regulation of melanoma drivers

Cytoplasmic polyadenylated transcripts have been poorly characterized, particularly in cancer. Here the authors identify a lineage-specific requirement of the cytoplasmic polyadenylation binding protein 4 (CPEB4) in malignant melanoma and show that it controls melanoma drivers MITF and RAB27A.

Eva Pérez-Guijarro
Panagiotis Karras
María S. Soengas
ResearchOpen Access18 Nov 2016
Nature Communications

Volume: 7, P: 1-17
Lipid droplet degradation by autophagy connects mitochondria metabolism to Prox1-driven expression of lymphatic genes and lymphangiogenesis

Autophagy is essential to endothelial cell homeostasis. Here the authors show that lipophagy in LEC supports fatty acid oxidation to sustain a mitochondrial-Prox1 gene expression circuit and promote response of LEC to lymphangiogenic mediators.

Odeta Meçe
Diede Houbaert
Patrizia Agostinis
ResearchOpen Access19 May 2022
Nature Communications

Volume: 13, P: 1-18
Midkine rewires the melanoma microenvironment toward a tolerogenic and immune-resistant state

Tumor-secreted midkine modulates immune tolerance in the melanoma tumor microenvironment and determines resistance to immune checkpoint blockade.

Daniela Cerezo-Wallis
Marta Contreras-Alcalde
María S. Soengas
Research19 Oct 2020
Nature Medicine

Volume: 26, P: 1865-1877
p53 and p73: seeing double?

Whereas p73 is closely related to the tumour-suppressor protein p53, its contribution to tumour suppression and the spatial and temporal regulation of its isoforms is unclear. It has now been established that p73 is a transcriptional target of E2F1. Its ability to induce apoptosis in TP53^−/− cells indicates a tumour-control mechanism that runs parallel to but independent of that mediated by p53. The new results illustrate a complex cross-talk between p53, E2F1 and p73.

María S Soengas
Scott W Lowe
News & Views01 Dec 2000
Nature Genetics

Volume: 26, P: 391-392
Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1

Hundreds of mRNA binding proteins (mRBPs) have been described in mammalian cells. Here, the authors identify RBPs differentially regulated in melanoma, and show the RBP CELF1 controlling a distinct set of protumorigenic factors.

Metehan Cifdaloz
Lisa Osterloh
María S. Soengas
ResearchOpen Access21 Dec 2017
Nature Communications

Volume: 8, P: 1-18
AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest

Malumbres and colleagues reveal that mitotic arrest is accompanied by reduced mitochondrial mass and oxidative respiration resulting in activation of AMPK and induction of glycolysis to promote cell survival.

Elena Doménech
Carolina Maestre
Marcos Malumbres
Research31 Aug 2015
Nature Cell Biology

Volume: 17, P: 1304-1316
Whole-body imaging of lymphovascular niches identifies pre-metastatic roles of midkine

Genetically engineered ‘lymphoreporter’ mouse strains are used to track melanoma dissemination in vivo, identifying midkine as a tumour-secreted factor that acts at a distance, preparing pre-metastatic niches and serving as an indicator of poor prognosis in patients.

David Olmeda
Daniela Cerezo-Wallis
María S. Soengas
Research28 Jun 2017
Nature

Volume: 546, P: 676-680
p53-mediated up-regulation of CD95 is not involved in genotoxic drug-induced apoptosis of human breast tumor cells

María del Carmen Ruiz-Ruiz
Abelardo López-Rivas
Research12 Mar 1999
Cell Death & Differentiation

Volume: 6, P: 271-280

Search

Apoptosis and melanoma chemoresistance

The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2

Repriming of DNA synthesis at stalled replication forks by human PrimPol

Cell position matters in tumour development

Systemic rewiring of dendritic cells by melanoma-secreted midkine impairs immune surveillance and response to immune checkpoint blockade

Inactivation of the apoptosis effector Apaf-1 in malignant melanoma

Lineage-specific roles of the cytoplasmic polyadenylation factor CPEB4 in the regulation of melanoma drivers

Lipid droplet degradation by autophagy connects mitochondria metabolism to Prox1-driven expression of lymphatic genes and lymphangiogenesis

Midkine rewires the melanoma microenvironment toward a tolerogenic and immune-resistant state

p53 and p73: seeing double?

Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1

AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest

Whole-body imaging of lymphovascular niches identifies pre-metastatic roles of midkine

p53-mediated up-regulation of CD95 is not involved in genotoxic drug-induced apoptosis of human breast tumor cells

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