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Showing 1–3 of 3 results
Advanced filters: Author: Mar Gonzàlez-Porta Clear advanced filters

  • Renal cancer accounts for 2.4% of all adult cancers and its incidence is increasing worldwide. Here, the authors carry out genome and transcriptome sequencing of clear cell renal cell carcinomas (ccRCCs) and highlight genomic aberrations and biological pathways underlying ccRCC tumorigenesis.

    • Ghislaine Scelo
    • Yasser Riazalhosseini
    • G. Mark Lathrop
    Research
    Nature Communications
    Volume: 5, P: 1-13

  • Sequencing and deep analysis of mRNA and miRNA from lymphoblastoid cell lines of 462 individuals from the 1000 Genomes Project reveal widespread genetic variation affecting the regulation of most genes, with transcript structure and expression level variation being equally common but genetically largely independent, and the analyses point to putative causal variants for dozens of disease-associated loci.

    • Tuuli Lappalainen
    • Michael Sammeth
    • Emmanouil T. Dermitzakis
    Research
    Nature
    Volume: 501, P: 506-511