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DNMT3B supports meso-endoderm differentiation from mouse embryonic stem cells

DNMT3B-dependent DNA methylation provides epigenetic priming at epiblast stage by methylating enhancers of ectodermal genes to ensure proper differentiation toward mesoendoderm tissues.

Andrea Lauria
Guohua Meng
Salvatore Oliviero
ResearchOpen Access23 Jan 2023
Nature Communications

Volume: 14, P: 1-18
The transcriptional regulator ZNF398 mediates pluripotency and epithelial character downstream of TGF-beta in human PSCs

The downstream pathway regulating how TGF-beta affects pluripotency of human PSCs is unclear. Here, the authors find that transcription factor ZNF398 binds active promoters/enhancers together with the histone acetyltransferase EP300 and SMAD3, enabling expression of pluripotency and epithelial genes.

Irene Zorzan
Marco Pellegrini
Graziano Martello
ResearchOpen Access12 May 2020
Nature Communications

Volume: 11, P: 1-16
Intragenic DNA methylation prevents spurious transcription initiation

Intragenic DNA methylation, dependent on Dnmt3b, protects the gene body from spurious entry of RNA Polymerase II and aberrant transcription initiation events.

Francesco Neri
Stefania Rapelli
Salvatore Oliviero
Research22 Feb 2017
Nature

Volume: 543, P: 72-77

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