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Showing 1–24 of 24 results
Advanced filters: Author: Marc Baldus Clear advanced filters

  • Integrated structural data show that the MAP7 microtubule binding domain stabilizes the microtubule lattice through binding along protofilaments. Both strong and weak interactions between MAP7 and the lattice extend beyond a single tubulin dimer and include the tubulin C-terminal tails.

    • Agnes Adler
    • Mamata Bangera
    • Marc Baldus
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • Microtubule (MT) organization is regulated by many microtubule-associated proteins (MAPs) that contain intrinsically disordered regions. Here authors produce [13C, 15N] labeled, functional microtubules from human cells for solid-state NMR which allows studying MAP-MT interactions.

    • Yanzhang Luo
    • ShengQi Xiang
    • Marc Baldus
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • Processing bodies are membrane less organelles that contain enzymes involved in mRNA turnover, among them enhancer of decapping 3 (Edc3). Here the authors use solid- and solution-state NMR spectroscopy to characterize the structural organization and dynamics of Edc3 and find that its interactions with RNA and between the different Edc3 domains are largely preserved in the phase-separated state.

    • Reinier Damman
    • Stefan Schütz
    • Marc Baldus
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • CKK domain containing CAMSAP/Patronins recognise and regulate microtubule (MT) minus end dynamics. Here the authors compare cryo-EM structures of MT-bound human CKK and Naegleria gruberi CKK which lacks minus-end binding preference, finding NgCKK has a different interaction with, and inability to remodel, its MT binding site, shedding light on the CAMSAP/Patronin end binding mechanism.

    • Joseph Atherton
    • Yanzhang Luo
    • Carolyn A. Moores
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16

  • The β-barrel assembly machinery (BAM) catalyzes β-barrel protein insertion into the outer membrane of E.coli. Here authors employ high-sensitivity solid-state NMR to reveal how the lipid environment and formation of the BamA-BamCDE complex affect BamA structure and dynamics with regards to the lateral gate and the β-barrel associated domains.

    • Cecilia Pinto
    • Deni Mance
    • Marc Baldus
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10

  • Preclinical molecular models are useful that mimic a patient´s response to targeted therapy. Here, the authors establish an in vivo inducible RNAi-mediated gene silencing system in patient-derived xenograft models of acute leukemia to identify individual vulnerabilities and therapeutic targets.

    • Michela Carlet
    • Kerstin Völse
    • Irmela Jeremias
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • DcuS is a multidomain membrane sensor kinase important for Escherichia coli interactions with its environment. A new approach combining solution- and solid-state NMR with in silico modeling and mutagenesis has provided a three-dimensional model for most of this large membrane protein and suggests a mechanism for DcuS activation.

    • Manuel Etzkorn
    • Holger Kneuper
    • Marc Baldus
    Research
    Nature Structural & Molecular Biology
    Volume: 15, P: 1031-1039

  • The natural antibiotic teixobactin kills bacteria by direct binding to their cognate cell wall precursors (Lipid II and III). Here authors use solid-state NMR to reveal the native binding mode of teixobactins and show that teixobactins only weakly bind to Lipid II in anionic cellular membranes.

    • Rhythm Shukla
    • João Medeiros-Silva
    • Markus Weingarth
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • Spontaneous activity shifts at constant experimental conditions are widespread among ion channels but the molecular origins are poorly understood. Here, using solid-state NMR and MD simulations, the authors reveal that modal gating shifts in K + channels are caused by large shifts in the channel dynamics which perturb the selectivity filter.

    • Shehrazade Jekhmane
    • João Medeiros-Silva
    • Markus Weingarth
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • Elucidating the reaction mechanism of a catalytic process is very challenging. Now, advanced solid-state nuclear magnetic resonance experiments demonstrate the importance of oxygenates to regulate the conversion of synthesis gas over an oxide–zeolite-based bifunctional catalyst material.

    • Marc Baldus
    • Bert M. Weckhuysen
    News & Views
    Nature Catalysis
    Volume: 5, P: 584-585

  • Antibiotics that target the peptidoglycan precursor lipid II are promising templates for next-generation antibiotics. Here authors use solid-state NMR and monitor lipid II-binding antibiotics, such as nisin, directly in cell membranes.

    • João Medeiros-Silva
    • Shehrazade Jekhmane
    • Markus Weingarth
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10

  • G-protein-coupled receptors (GPCRs) are critically involved in signal transduction. Structural views of several GPCRs have recently been obtained, but the structural principles determining subtype selectivity are still mostly elusive. Now, a combined solid-state NMR and molecular-modeling approach reveals how bradykinin GPCRs distinguish between closely related peptide ligands.

    • Marc Baldus
    News & Views
    Nature Chemical Biology
    Volume: 14, P: 201-202

  • Type three secretion systems consist of a multisubunit protein complex that crosses the bacterial membranes and an extracellular needle-shaped structure. New data show that the needle protomer partially refolds from alpha-helix into beta-strand conformation to extend the needle from the distal end. The closely related flagellar system also grows at the tip, but it is not known whether protomer refolding is required for its assembly.

    • Ömer Poyraz
    • Holger Schmidt
    • Michael Kolbe
    Research
    Nature Structural & Molecular Biology
    Volume: 17, P: 788-792

  • Bioethanol-based alkylation of benzene is a potentially sustainable route to commodity chemicals, but there is little knowledge of the reaction mechanism. Here, Weckhuysen and co-workers study the zeolite catalysed alkylation of benzene with ethanol, identifying the active alkylating agent and experimentally show the presence of a σ-complex intermediate.

    • Abhishek Dutta Chowdhury
    • Klaartje Houben
    • Bert M. Weckhuysen
    Research
    Nature Catalysis
    Volume: 1, P: 23-31