N-methyl-D-aspartate (NMDA) receptors have different opening probabilities and pharmacological profiles according to the type of NR2 subunit they possess (NR2A to NR2D). The region formed by the NR2 amino-terminal domain, and the short linker connecting this to the agonist-binding domain, are now shown to be responsible for controlling the subunit-specific gating of NMDA receptors.
- Marc Gielen
- Beth Siegler Retchless
- Pierre Paoletti
