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Showing 1–4 of 4 results
Advanced filters: Author: Marc Giry-Laterriere Clear advanced filters

  • A whole-genome sequencing analysis of 100 pancreatic ductal adenocarcinomas has discovered known and newly identified genetic drivers of pancreatic cancer; these genetic alterations can be classified into four subtypes, which raises the possibility of improved targeting of clinical treatments.

    • Nicola Waddell
    • Marina Pajic
    • Sean M. Grimmond
    Research
    Nature
    Volume: 518, P: 495-501

  • An integrated genomic analysis of 456 human pancreatic ductal adenocarcinomas identifies four subtypes defined by transcriptional expression profiles and show that these are associated with distinct histopathological characteristics and differential prognosis.

    • Peter Bailey
    • David K. Chang
    • Sean M. Grimmond
    Research
    Nature
    Volume: 531, P: 47-52

  • SLIT-ROBO alterations arise in pancreatic ductal adenocarcinoma (PDAC), but their role in the pancreas is unclear. Here, the authors use mouse models to show that loss of epithelial Robo2 activates the neighbouring stroma via TGF-β signalling; findings  are relevant to PDAC patients, where ROBO expression correlates with survival outcomes.

    • Andreia V. Pinho
    • Mathias Van Bulck
    • Ilse Rooman
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14

  • Exome sequencing and copy number analysis are used to define genomic aberrations in early sporadic pancreatic ductal adenocarcinoma; among the findings are mutations in genes involved in chromatin modification and DNA damage repair, and frequent and diverse somatic aberrations in genes known as embryonic regulators of axon guidance.

    • Andrew V. Biankin
    • Nicola Waddell
    • Sean M. Grimmond
    Research
    Nature
    Volume: 491, P: 399-405