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Showing 1–5 of 5 results
Advanced filters: Author: Marc Graille Clear advanced filters

  • Three surveillance pathways specialize in the degradation of mRNA molecules trapped in stalled translation complexes: the non-stop decay (NSD), the no-go decay (NGD) and the 18S-rRNA decay (18S-NRD) pathways. These quality control mechanisms degrade faulty mRNAs and contribute to maintaining the production of functional proteins.

    • Marc Graille
    • Bertrand Séraphin
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 13, P: 727-735

  • Dom34 and Hbs1 are involved in no-go decay (NGD) and nonfunctional 18S rRNA decay (18S NRD) pathways that eliminate RNAs causing translation stalling. Now structural work reveals the similarity of the Dom34–Hbs1 complex with elongation factor–tRNA and translation termination eRF1–eRF3 complexes. Mutagenesis analysis of Hbs1 shows that NGD and 18S NRD can be genetically uncoupled.

    • Antonia M G van den Elzen
    • Julien Henri
    • Marc Graille
    Research
    Nature Structural & Molecular Biology
    Volume: 17, P: 1446-1452

  • In fission yeast, the antagonistic RNA-binding proteins Mmi1 and Mei2 respectively promote and inhibit meiotic mRNA degradation during mitotic growth. Here the authors show that the lncRNA mamRNA scaffolds Mmi1 and Mei2 proteins to enable their mutual controls.

    • Vedrana Andric
    • Alicia Nevers
    • Mathieu Rougemaille
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12