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Showing 1–5 of 5 results
Advanced filters: Author: Marc Kschonsak Clear advanced filters

  • Structural and functional studies of the sodium leak channel, non-selective (NALCN) in complex with a distinct auxiliary subunit reveal the structural basis of the channel function and pharmacology and the functional impact of mutations that cause NALCN channelopathies.

    • Marc Kschonsak
    • Han Chow Chua
    • Jian Payandeh
    Research
    Nature
    Volume: 587, P: 313-318

  • SMARCA4 is the core catalytic subunit of the mammalian SWI/SNF complex and is known to be mutated in many cancers. Here, the authors detect more than 10,000 SMARCA4 variants across different cancer subtypes and find hotspot mutations throughout the helicase domain, which reduce remodeling activity.

    • Tharu M. Fernando
    • Robert Piskol
    • Robert L. Yauch
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

  • Cryo-EM structures of the S. cerevisiae condensin holo complex reveal that ATP binding triggers exchange of the two HEAT-repeat subunits bound to the SMC ATPase head domains, potentially leading to an interconversion of DNA-binding sites in the catalytic core of condensin that might form the basis of its DNA translocation and loop-extrusion activities.

    • Byung-Gil Lee
    • Fabian Merkel
    • Christian H. Haering
    Research
    Nature Structural & Molecular Biology
    Volume: 27, P: 743-751