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Showing 1–3 of 3 results
Advanced filters: Author: Marc Niere Clear advanced filters

  • Modulating mitochondrial NAD+ levels by changing the expression of the mitochondrial NAD+ transporter, SLC25A51, Mukherjee et al. demonstrate that mitochondrial, rather than cytosolic or nuclear, NAD+ levels are a key determinant of the rate of liver regeneration.

    • Sarmistha Mukherjee
    • Ricardo A. Velázquez Aponte
    • Joseph A. Baur
    ResearchOpen Access
    Nature Metabolism
    Volume: 7, P: 2424-2437

  • By increasing NAD+ consumption in various organelles, mitochondria are revealed to act as buffers that help maintain subcellular NAD+ levels. At the same time, cells are found to be particularly sensitive to a decline in NAD+ levels originating from mitochondria themselves.

    • Lena E. Høyland
    • Magali R. VanLinden
    • Mathias Ziegler
    Research
    Nature Metabolism
    Volume: 6, P: 2319-2337

  • SLC25A51 is identified as a transporter of intact NAD+ into mammalian mitochondria and is required to maintain the mitochondrial NAD+ pool and respiratory function.

    • Timothy S. Luongo
    • Jared M. Eller
    • Joseph A. Baur
    Research
    Nature
    Volume: 588, P: 174-179