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Showing 1–25 of 25 results
Advanced filters: Author: Marc Veldhoen Clear advanced filters

  • A newly identified, TGFβ-inducible decoy receptor for IL-17 family cytokines reveals a feedback mechanism that limits mucosal inflammation, linking epithelial and lymphoid cell responses through a common cytokine axis that controls IL-17-driven immunity.

    • Marc Veldhoen
    News & Views
    Nature Immunology
    P: 1-3

  • Type-1 regulatory T cells promoted the generation of CD8+ tissue-resident memory T (TRM) cells during intracellular infections in the gut. Here, the authors show that the establishment TRM cells more broadly depends on the presence of regulatory T cells matching the type of infection.

    • Leandro Barros
    • Daryna Piontkivska
    • Cristina Ferreira
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • Here, Veldhoen and Simas discuss why immunity to SARS-CoV-2 in populations may ultimately be driven by the endemic presence of the virus and not rely on continued mass vaccination programmes.

    • Marc Veldhoen
    • J. Pedro Simas
    Comments & Opinion
    Nature Reviews Immunology
    Volume: 21, P: 131-132

  • 3-hydroxy-L-kynurenamine (3-HKA) is a metabolite deriving from a lateral pathway of tryptophan catabolism. Here the authors identify 3-HKA as a biogenic amine and show it has anti-inflammatory properties that can protect mice against psoriasis and nephrotoxic nephritis.

    • Cristina C. Clement
    • Angelo D’Alessandro
    • Laura Santambrogio
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • There are clear epidemiological links between nutrition and immunological function, but a dearth of mechanistic insights has made this topic controversial. Veldhoen and Veiga-Fernandes discuss this controversy and explore ways to take this research forward.

    • Marc Veldhoen
    • Henrique Veiga-Fernandes
    Comments & Opinion
    Nature Immunology
    Volume: 16, P: 215-219

  • Immunohomeostasis prevents pathology resulting from immune activation. Two new studies link its regulation with the activation of the aryl hydrocarbon receptor, a known mediator of the toxic effects of xenobiotic ligands, in a subset of T lymphocytes.

    • Marc Veldhoen
    News & Views
    Nature Immunology
    Volume: 11, P: 779-781

  • Three new studies demonstrate that development of human TH-17 cells requires transforming growth factor-β and one or more proinflammatory cytokines, which are the same requirements as for mouse TH-17 development.

    • Anne O'Garra
    • Brigitta Stockinger
    • Marc Veldhoen
    News & Views
    Nature Immunology
    Volume: 9, P: 588-590

  • Although interleukin 17 (IL-17) has modest activity on its own, it has a substantial impact in immunity through its synergistic action with other factors and its self-sustaining feedback loop. Veldhoen discusses the role of IL-17 during infections.

    • Marc Veldhoen
    Reviews
    Nature Immunology
    Volume: 18, P: 612-621

  • Dietary habits have always been associated with the robustness of the immune system. Here, the molecular links between dietary compounds and immune regulation in the intestine are discussed, with a focus on the central role of nuclear receptors.

    • Marc Veldhoen
    • Verena Brucklacher-Waldert
    Reviews
    Nature Reviews Immunology
    Volume: 12, P: 696-708

  • The receptor for interleukin-7 is a susceptibility factor in multiple sclerosis, but its exact role in the disease has been unclear. New findings outline a function for interleukin-7 in the biology of T helper 17 cells, a subset of T cells recently identified as key players in autoimmune disorders (pages 191–197).

    • Marc Veldhoen
    • Benedict Seddon
    News & Views
    Nature Medicine
    Volume: 16, P: 166-168

  • Fat-associated lymphoid clusters are lymphoid tissues that support B-1 cells. Caamaño and colleagues show that inflammation that elicits the cytokine TNF and activates natural killer cells contributes to the formation of these clusters in visceral fat.

    • Cécile Bénézech
    • Nguyet-Thin Luu
    • Jorge H Caamaño
    Research
    Nature Immunology
    Volume: 16, P: 819-828

  • The reasons why malaria manifests with a variety of well-recognized clinical phenotypes remain poorly understood. Here, using distinct rodent models, the authors reveal that the microbiota colonizing the lung promotes respiratory distress syndrome and mortality during malaria infections.

    • Debanjan Mukherjee
    • Ângelo Ferreira Chora
    • Maria M. Mota
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14

  • Here, the authors generate a single-cell DNA methylation and transcriptome dataset from mouse peripheral blood samples, spanning a broad range of ages. They next develop scEpiAge, a single-cell DNA methylation age predictor.

    • Marc Jan Bonder
    • Stephen J. Clark
    • Ferdinand von Meyenn
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • Despite the consensus that mass vaccination against SARS-CoV-2 will ultimately end the pandemic, it is not clear when and which control measures can be relaxed during the rollout of vaccination programmes. Here, the authors investigate relaxation scenarios using an age-structured transmission model that has been fitted to data for Portugal.

    • João Viana
    • Christiaan H. van Dorp
    • Ganna Rozhnova
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • Although in vitro–generated cells of the TH17 helper T cell subset are highly plastic, it is unclear whether TH17 cells that develop in vivo retain their phenotype. To investigate this, Stockinger and colleagues have generated a TH17 reporter system to map the fate of these cells in vivo.

    • Keiji Hirota
    • João H Duarte
    • Brigitta Stockinger
    Research
    Nature Immunology
    Volume: 12, P: 255-263

  • Histone post-translational modifications are known key regulators of gene expression. Here, the authors characterize histone crotonylation at histone H3 lysine 18 in intestinal epithelia and find that it is a highly dynamic cell cycle regulated mark under the regulation of the HDAC deacetylases.

    • Rachel Fellows
    • Jérémy Denizot
    • Patrick Varga-Weisz
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-15

  • Recent studies have provided insight into how the environment, and in particular the diet, influence the development of lymphocytes. Emerging studies indicate a role for this immune development in inflammatory disease.

    • Marc Veldhoen
    • Cristina Ferreira
    Reviews
    Nature Medicine
    Volume: 21, P: 709-718