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Showing 1–6 of 6 results
Advanced filters: Author: Marcel Hollenstein Clear advanced filters

  • Chemical modification of DNA is a common strategy to improve the properties of oligonucleotides. Herein, the authors report a robust method based on the template-dependent DNA ligation of shortmer fragments by DNA ligases, which is compatible with numerous chemical modifications and applicable to short (~20 nt) and longer (<100 nt) sequences.

    • Nazarii Sabat
    • Andreas Stämpfli
    • Marcel Hollenstein
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-12

  • Research on enzymatic RNA synthesis has long been eclipsed by work on DNA—but a new method provides a leap forward for RNA.

    • Marcel Hollenstein
    News & Views
    Nature Biotechnology
    Volume: 43, P: 691-693

  • Chemical modifications of aptamers can enhance binding properties, however, the design of suitable functional groups remains challenging. Here, the authors introduce cyclooctatetraene (COT)-modified nucleotides in SELEX experiments, identifying COT-aptamers with low nM dissociation constants, highlighting the potential of three-dimensional ligands in aptamer discovery.

    • Greta Charlotte Dahm
    • Usman Akhtar
    • Marcel Hollenstein
    ResearchOpen Access
    Communications Chemistry
    Volume: 8, P: 1-10

  • Controlled enzymatic DNA synthesis represents an alternative synthetic methodology that circumvents the limitations of traditional soild-phase synthesis. Here, the authors explore the use of 3’-phosphate as a transient protecting group for the controlled enzymatic synthesis of DNA and XNA oligonucleotides.

    • Marie Flamme
    • Steven Hanlon
    • Marcel Hollenstein
    ResearchOpen Access
    Communications Chemistry
    Volume: 5, P: 1-12

  • Nucleic acids are key elements in numerous applications such as therapeutics and nanotechnology. However, the synthesis of long and modified oligonucleotides remains challenging and alternative, biocatalytic approaches are needed. Here, the authors discuss recent progress in the controlled enzymatic synthesis of oligonucleotides.

    • Maëva Pichon
    • Marcel Hollenstein
    ReviewsOpen Access
    Communications Chemistry
    Volume: 7, P: 1-11