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Showing 1–6 of 6 results
Advanced filters: Author: Marcel van ’t Hoff Clear advanced filters
  • A20, encoded by TNFAIP3, is a negative-feedback inhibitor of NF-κB. Grey and colleagues identify natural human variants of TNFAIP3, which lower A20 activity and increase autoinflammatory responses. These alleles were inherited by descendants of Denisovans who crossed the Wallace Line to inhabit Oceania.

    • Nathan W. Zammit
    • Owen M. Siggs
    • Shane T. Grey
    Research
    Nature Immunology
    Volume: 20, P: 1299-1310
  • Measurements in the CLOUD chamber at CERN show that the rapid condensation of ammonia and nitric acid vapours could be important for the formation and survival of new particles in wintertime urban conditions, contributing to urban smog.

    • Mingyi Wang
    • Weimeng Kong
    • Neil M. Donahue
    ResearchOpen Access
    Nature
    Volume: 581, P: 184-189
  • Network activity in primary motor cortex (M1) controls dexterous limb movements. Here, the authors show that the M1 population code varies according to contextual motor demands that are conveyed via the secondary motor cortex (M2).

    • Wolfgang Omlor
    • Anna-Sophia Wahl
    • Fritjof Helmchen
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16
  • Analyses of genomes from 914 children, adolescents, and young adults provide a comprehensive resource of genomic alterations across a spectrum of common childhood cancers.

    • Susanne N. Gröbner
    • Barbara C. Worst
    • Stefan M. Pfister
    ResearchOpen Access
    Nature
    Volume: 555, P: 321-327
  • Focusing on two ill-characterized subtypes of medulloblastoma (group 3 and group 4), this study identifies prevalent genomic structural variants that are restricted to these two subtypes and independently bring together coding regions of GFI1 family proto-oncogenes with active enhancer elements, leading to their mutually exclusive oncogenic activation.

    • Paul A. Northcott
    • Catherine Lee
    • Stefan M. Pfister
    Research
    Nature
    Volume: 511, P: 428-434