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Showing 1–2 of 2 results
Advanced filters: Author: Marceline M. Fuh Clear advanced filters
  • Transcriptional crosstalk between inflammation and energy metabolism within cardiomyocytes remains unclear. Here, the authors identify IRF3/PGC-1α as a bidirectional transcriptional nexus between IFN response and mitochondrial oxidative phosphorylation in cardiomyocytes altering cardiac function.

    • Manju Kumari
    • Ioannis Evangelakos
    • Norbert Frey
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-27
  • Polyunsaturated Fatty Acids (PUFA), such as omega-3 fatty acids, are recognized for their lipid lowering and anti-inflammatory properties. Here, the authors show that endogenous lipid synthesis controls the use of PUFA and thus determine the therapeutic benefit of omega-3 fatty acid supplementation.

    • Anna Worthmann
    • Julius Ridder
    • Christian Schlein
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13