Cells lining the kidney proximal tubule are densely packed with lysosomes, but little is known about their dynamic activity in situ. Here, the authors use intravital imaging and targeted probes to study lysosomal behavior along the kidney proximal tubule, and discover substantial axial heterogeneity in lysosomal dynamics, organellar interactions and metabolic functions.
- Monika Kaminska
- Imene B. Sakhi
- Andrew M. Hall
