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Showing 1–4 of 4 results
Advanced filters: Author: Marcellus Augustine Clear advanced filters
  • Multiple synchronous lung cancers (MSLCs) are a subtype of lung cancer. Here the authors characterise MSLCs using single cell RNA sequencing, single cell TCR sequencing and bulk whole-exome sequencing to investigate the mutations that arise in and are associated with invasive adenocarcinoma development, and immune microenvironment changes in this process.

    • Yue Zhao
    • Jian Gao
    • Haiquan Chen
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14
  • Combination of epidemiology, preclinical models and ultradeep DNA profiling of clinical cohorts unpicks the inflammatory mechanism by which air pollution promotes lung cancer

    • William Hill
    • Emilia L. Lim
    • Charles Swanton
    Research
    Nature
    Volume: 616, P: 159-167
  • The spatial and physical nature of tumour growth remains unclear. Combining whole-tumour images from clear cell renal cell carcinoma with genomic data, the authors show more aggressive subclonal growth and metastasizing subclones in the tumour centre.

    • Yue Zhao
    • Xiao Fu
    • Kevin Litchfield
    Research
    Nature Ecology & Evolution
    Volume: 5, P: 1033-1045
  • A combined modelling and tumour analysis approach is used to study the temporal and spatial patterns of subclone evolution in the TRACERx renal study. Studying the tumour shape and spatial features of clonal diversity in early-stage tumours may allow the prediction of tumour progression and patterns of subclone diversification over time.

    • Xiao Fu
    • Yue Zhao
    • Paul A. Bates
    ResearchOpen Access
    Nature Ecology & Evolution
    Volume: 6, P: 88-102