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Showing 1–7 of 7 results
Advanced filters: Author: Marcin J. Suskiewicz Clear advanced filters

  • Baretić and Missoury et al. identify vertebrate proteins FAM118B and FAM118A as sirtuins similar to bacterial antiphage enzymes and show that FAM118A/B processing of NAD involves head-to-tail filament formation and a partnership between the two paralogs.

    • Domagoj Baretić
    • Sophia Missoury
    • Marcin J. Suskiewicz
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 32, P: 2526-2541

  • PARP inhibitors function by trapping PARP1 protein on DNA breaks, which has cytotoxic consequences to cancer cells. Here the authors identify three serine residues within PARP1 as key sites whose efficient HPF1-dependent modification counters PARP1 trapping and contributes to inhibitor tolerance.

    • Evgeniia Prokhorova
    • Florian Zobel
    • Ivan Ahel
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • Structural and biochemical characterization of arginine kinase McsB reveals how its phosphagen kinase–like catalytic domain is adapted to target protein substrates while its phosphoarginine-binding domain allosterically controls kinase activity.

    • Marcin J. Suskiewicz
    • Bence Hajdusits
    • Tim Clausen
    Research
    Nature Chemical Biology
    Volume: 15, P: 510-518

  • The PARP2–HPF1 histone-modifying complex bridges two nucleosomes to align broken DNA ends for ligation, initiating conformational changes that activate PARP2 and enable DNA damage repair.

    • Silvija Bilokapic
    • Marcin J. Suskiewicz
    • Mario Halic
    Research
    Nature
    Volume: 585, P: 609-613