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Showing 1–5 of 5 results
Advanced filters: Author: Marcin Skwark Clear advanced filters

  • InstaNovo, a transformer-based model, and InstaNovo+, a multinomial diffusion model, enhance de novo peptide sequencing, enabling discovery of novel peptides, improved therapeutics sequencing coverage and detection of unreported organisms in proteomics studies

    • Kevin Eloff
    • Konstantinos Kalogeropoulos
    • Timothy P. Jenkins
    ResearchOpen Access
    Nature Machine Intelligence
    Volume: 7, P: 565-579

  • Antibiotic resistance and virulence factors are identified in Mycobacterium abscessus by integrating proteome-wide structural modelling, GWAS analyses and mapping gene interaction networks for 331 clinical isolates.

    • Lucas Boeck
    • Sophie Burbaud
    • R. Andres Floto
    ResearchOpen Access
    Nature Microbiology
    Volume: 7, P: 1431-1441

  • Here the authors describe multiple structures of the replicative helicase MCM2-7 in complex with Dbf4-dependent kinase (DDK). These structures reveal why the kinase specifically recognizes the MCM2-7 double-hexamer over the single-hexamer and explain how DDK can phosphorylate distantly located Mcm tails.

    • Almutasem Saleh
    • Yasunori Noguchi
    • Christian Speck
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-20

  • A DNA-based large language model, AgroNT, trained on multiple plant genomes, can accurately predict various molecular phenotypes within plant species, including important crops.

    • Javier Mendoza-Revilla
    • Evan Trop
    • Marie Lopez
    ResearchOpen Access
    Communications Biology
    Volume: 7, P: 1-18