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Showing 1–4 of 4 results
Advanced filters: Author: Marco Barazas Clear advanced filters

  • 53BP1 is a key player in non-homologous end joining (NHEJ). Here the authors reveal an important role for the multifunctional homodimeric protein hub dynein light chain 1 (DYNLL1) in increasing the efficacy of 53BP1-mediated repair of DNA double-strand breaks (DSBs) by NHEJ.

    • Jordan R. Becker
    • Raquel Cuella-Martin
    • J. Ross Chapman
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12

  • The 53BP1 effector complex shieldin is involved in non-homologous end-joining and immunoglobulin class switching, and acts to protect DNA ends to facilitate the repair of DNA by 53BP1.

    • Sylvie M. Noordermeer
    • Salomé Adam
    • Daniel Durocher
    Research
    Nature
    Volume: 560, P: 117-121

  • Loss of REV7 is shown to regulate end resection of double-stranded DNA breaks in BRCA1-deficient cells, leading to PARP inhibitor resistance and restoration of homologous recombination; REV7 dictates pathway choice in BRCA1-deficient cells and during immunoglobulin class switching.

    • Guotai Xu
    • J. Ross Chapman
    • Sven Rottenberg
    Research
    Nature
    Volume: 521, P: 541-544