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Defective maintenance of intracellular Ca²⁺ homeostasis is linked to increased muscle fatigability in the MG29 null mice

Marco A P BROTTO
Ramakrishnan Y NAGARAJ
Thomas M NOSEK
Research01 Oct 2004
Cell Research

Volume: 14, P: 373-378
Excitation-Contraction Coupling in the Day 15 Embryonic Chick Heart with Persistent Truncus Arteriosus

Tony L Creazzo
Marco A P Brotto
Jarrett Burch
Research01 Dec 1997
Pediatric Research

Volume: 42, P: 731-737
Deficiency of MIP/MTMR14 phosphatase induces a muscle disorder by disrupting Ca²⁺ homeostasis

Mutations in the MIP phosphatase MTMR14 are associated with human autosomal centronuclear myopathy. Mice that lack MIP have impaired muscle performance and enhanced fatigue due to the accumulation of MIP substrates PtdIns(3,5)P2 and PtdIns(3,4)P2, which cause alterations in intracellular Ca2+ levels.

Jinhua Shen
Wen-Mei Yu
Cheng-Kui Qu
Research24 May 2009
Nature Cell Biology

Volume: 11, P: 769-776
Uncontrolled calcium sparks act as a dystrophic signal for mammalian skeletal muscle

Xu Wang
Noah Weisleder
Jianjie Ma
Research17 Apr 2005
Nature Cell Biology

Volume: 7, P: 525-530
A mechanical model for lateral and axial impacts and quantification of effect on viability of SHSY5Y neuroblastoma cells

Raisa Akhtaruzzaman
Kamal Awad
Ashfaq Adnan
ResearchOpen Access03 Jun 2025
Scientific Reports

Volume: 15, P: 1-14
The toxic effects of chloroquine and hydroxychloroquine on skeletal muscle: a systematic review and meta-analysis

Claudia Cristina Biguetti
Joel Ferreira Santiago Junior
Marco Brotto
ResearchOpen Access23 Mar 2021
Scientific Reports

Volume: 11, P: 1-13
MG53 nucleates assembly of cell membrane repair machinery

A phosphatidylserine-binding protein, MG53, is shown to participate in membrane repair. MG53 recruits vesicles to the repair site in an oxidation dependent manner and MG53-null mice develop progressive myopathy associated with defective membrane repair.

Chuanxi Cai
Haruko Masumiya
Jianjie Ma
Research30 Nov 2008
Nature Cell Biology

Volume: 11, P: 56-64
γ-Aminobutyric acids (GABA) and serum GABA/AABA (G/A) ratio as potential biomarkers of physical performance and aging

Charalampos Lyssikatos
Zhiying Wang
Marco Brotto
ResearchOpen Access10 Oct 2023
Scientific Reports

Volume: 13, P: 1-16
Quantification of aminobutyric acids and their clinical applications as biomarkers for osteoporosis

Wang et al. develop an LC/MS based screening method to separate and quantify aminobutyric acids isoforms. Applying it to osteoporosis clinical studies, their method yields important correlations with bone mineral density and osteoporotic fracture and highlight the role of γ-aminobutyric acid and β-aminoisobutyric acid as biomarkers for osteoporosis.

Zhiying Wang
Liangqiao Bian
Marco Brotto
ResearchOpen Access22 Jan 2020
Communications Biology

Volume: 3, P: 1-14
l-β-aminoisobutyric acid, L-BAIBA, a marker of bone mineral density and body mass index, and D-BAIBA of physical performance and age

Charalampos Lyssikatos
Zhiying Wang
Lynda Bonewald
ResearchOpen Access11 Oct 2023
Scientific Reports

Volume: 13, P: 1-12
Characterization of a novel murine Sost ER^T2 Cre model targeting osteocytes

Delphine B. Maurel
Tsutomu Matsumoto
Lynda F. Bonewald
ResearchOpen Access21 Feb 2019
Bone Research

Volume: 7, P: 1-13

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