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Showing 1–3 of 3 results
Advanced filters: Author: Marco Canossa Clear advanced filters

  • Crystalline materials’ properties are highly dependent on their size. Here authors report a general synthesis of ultrasmall (4–6 nm) and highly defective Zr/Hf-Metal Organic Frameworks nanoparticles that present enhanced peptide hydrolysis performance.

    • Shan Dai
    • Charlotte Simms
    • Christian Serre
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-9

  • Beatrice Vignoli et al. examine potential molecular mechanisms of long-term storage information in mice. Their results suggest that astrocytes may help convert neuronal BDNF precursor into active prodomain and mature forms to enhance post-synaptic signaling and memory, providing further insight into the development of memory circuits.

    • Beatrice Vignoli
    • Gabriele Sansevero
    • Marco Canossa
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-17

  • Spagnolli, Massignan, Astolfi et al. design a new drug discovery approach, termed Pharmacological Protein Inactivation by Folding Intermediate Targeting, in which folding intermediates of disease-causing proteins are targeted. They test it on the cellular prion protein, identifying ligands stabilizing a folding intermediate and consequently promoting its degradation by the cellular quality control machinery.

    • Giovanni Spagnolli
    • Tania Massignan
    • Emiliano Biasini
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-16