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Showing 1–1 of 1 results
Advanced filters: Author: Marco Colamonici Clear advanced filters

  • Interferon alpha (IFNalpha) therapy is showing promising results to treat myeloproliferative neoplasms (MPNs). Here, the authors show that IFNalpha response requires ULK1 phosphorylation to induce p38-MAPK signalling but it is counteracted by ROCK1-2 activation suggesting combination therapy of IFNalpha-ROCK1-2 inhibition may improve MPNs treatment.

    • Diana Saleiro
    • Jeremy Q. Wen
    • Leonidas C. Platanias
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-19