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Showing 1–3 of 3 results
Advanced filters: Author: Marco Leibinger Clear advanced filters

  • Studies focussing on pharmacological manipulation of the kinase GSK3 have provided contradictory roles on the involvement of GSK3 in axon regeneration. Here Gobrecht et al., study transgenic mice with altered GSK3 signalling and show that in contrast to previous reports, GSK3 enhances axon regeneration.

    • Philipp Gobrecht
    • Marco Leibinger
    • Dietmar Fischer
    Research
    Nature Communications
    Volume: 5, P: 1-10

  • Loss of the PTEN protein, an event that activates PI3K/AKT signaling, in neurons enables axon regeneration. Now Leibinger et al show in retinal ganglion cells and during optic nerve regeneration in mice, that this is mediated by inactivation of the AKT substrate GSK3, which in turn releases axonal CRMP2 from GSK3-mediatated inhibition.

    • Marco Leibinger
    • Alexander M. Hilla
    • Dietmar Fischer
    ResearchOpen Access
    Communications Biology
    Volume: 2, P: 1-13

  • The CNS has limited ability to regenerate following injury, Here, the authors show that a single injection of AAV-hyper-interleukin-6 in the sensory motor cortex results in corticospinal and raphe spinal tracts regeneration in the injured spinal cord as well as functional recovery in mice.

    • Marco Leibinger
    • Charlotte Zeitler
    • Dietmar Fischer
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14