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Showing 1–9 of 9 results
Advanced filters: Author: Marco Montagner Clear advanced filters

  • The downstream pathway regulating how TGF-beta affects pluripotency of human PSCs is unclear. Here, the authors find that transcription factor ZNF398 binds active promoters/enhancers together with the histone acetyltransferase EP300 and SMAD3, enabling expression of pluripotency and epithelial genes.

    • Irene Zorzan
    • Marco Pellegrini
    • Graziano Martello
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • Recent findings suggest that forces acting on the cell nucleus can cause DNA damage, but the mechanisms are unclear. Here Takakiet al. report that actomyosin is a determinant of nuclear shape and that unrestrained contractility elicits nuclear envelope rupture and genome instability in cancer cells.

    • Tohru Takaki
    • Marco Montagner
    • Mark Petronczki
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13

  • Organ-like 3D cultures are advanced model system for biology and medicine limited by their uncontrolled cell self-assembly. Here, the authors develop a hydrogel-in-hydrogel bioprinting approach to dynamically control the growth landscape of a broad range of living 3D cell cultures.

    • Anna Urciuolo
    • Giovanni Giuseppe Giobbe
    • Nicola Elvassore
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • Romani et al. report that cells on soft extracellular matrix have increased mitochondrial fission, with subsequent production of mitochondrial reactive oxygen species and NRF2, which may increase resistance to reactive oxygen species-dependent chemotherapy drugs in breast cancer cells in vitro and in mouse lungs.

    • Patrizia Romani
    • Nunzia Nirchio
    • Sirio Dupont
    Research
    Nature Cell Biology
    Volume: 24, P: 168-180

  • Generation of the organizer tissue is induced on the dorsal side of the developing embryo by an asymmetry in Nodal signalling, which is only sufficiently high dorsally to induce organizer-specific gene expression. Now, through the identification of a microRNA (miR-15 and miR-16) that targets the Nodal receptor, microRNA is shown to have a role in this process.

    • Graziano Martello
    • Luca Zacchigna
    • Stefano Piccolo
    Research
    Nature
    Volume: 449, P: 183-188

  • Satellite cells have important roles in homeostasis and regeneration of skeletal muscles. Urciuolo et al. show that the extracellular matrix protein collagen VI is required for preserving satellite cell self-renewal and muscle regeneration in vitro and in vivoby modulating muscle mechanical properties.

    • Anna Urciuolo
    • Marco Quarta
    • Paolo Bonaldo
    Research
    Nature Communications
    Volume: 4, P: 1-13

  • Giulitti et al. deliver modified mRNAs encoding OCT3/4, SOX2, KLF4 and cMYC as well as NANOG in microfluidics to directly convert human fibroblasts into naive induced pluripotent stem cells; the confined environment leads to enhanced efficiency and homogeneity compared to traditional methods.

    • Stefano Giulitti
    • Marco Pellegrini
    • Graziano Martello
    Research
    Nature Cell Biology
    Volume: 21, P: 275-286