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Showing 1–4 of 4 results
Advanced filters: Author: Marco Pahor Clear advanced filters

  • The muscle-secreted, exercise-induced peptide hormone apelin decreases with aging and sarcopenia, and its repletion in aged mice with recombinant protein improves muscle mass and function.

    • Claire Vinel
    • Laura Lukjanenko
    • Cedric Dray
    Research
    Nature Medicine
    Volume: 24, P: 1360-1371

  • Temporal multi-omic analysis of tissues from rats undergoing up to eight weeks of endurance exercise training reveals widespread shared, tissue-specific and sex-specific changes, including immune, metabolic, stress response and mitochondrial pathways.

    • David Amar
    • Nicole R. Gay
    • Elena Volpi
    ResearchOpen Access
    Nature
    Volume: 629, P: 174-183

  • It is known that exercise influences many human traits, but not which tissues and genes are most important. This study connects transcriptome data collected across 15 tissues during exercise training in rats as part of the Molecular Transducers of Physical Activity Consortium with human data to identify traits with similar tissue specific gene expression signatures to exercise.

    • Nikolai G. Vetr
    • Nicole R. Gay
    • Stephen B. Montgomery
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • Although inhibition of the TOR signalling pathway extends lifespan in invertebrates, it was unknown whether mTOR signalling inhibition has similar effects in mammalian species. Here, feeding mice the drug rapamycin — an inhibitor of the mTOR pathway — late in life is shown to extend lifespan by 9–14%; currently, the only way to extend lifespan in rodents is by severe dietary restriction.

    • David E. Harrison
    • Randy Strong
    • Richard A. Miller
    Research
    Nature
    Volume: 460, P: 392-395