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Showing 1–3 of 3 results
Advanced filters: Author: Marco Pregnolato Clear advanced filters

  • The kinase PI3K is crucial for insulin signalling in the liver but the roles of individual PI3K isoforms are largely unclear. Using mice that lack class II PI3K isoform γ (PI3K-C2γ), the authors here show that PI3K-C2γ selectively activates endosomal Akt2 by regulating the localized production of PIP2.

    • Laura Braccini
    • Elisa Ciraolo
    • Emilio Hirsch
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-15

  • Transcription factors are critical regulators of cell identity. Here, the authors use computational and functional genomic approaches to show an oncogenic role of PAX8 in renal cancer. Mechanistic dissection of PAX8 functions reveal its role in activating genes associated with metabolic pathways.

    • Melusine Bleu
    • Swann Gaulis
    • Giorgio G. Galli
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10

  • BANP is identified as the transcription factor that binds the CGCG element in a DNA-methylation-dependent manner, opens chromatin and activates a class of essential CpG-island-regulated genes.

    • Ralph S. Grand
    • Lukas Burger
    • Dirk Schübeler
    Research
    Nature
    Volume: 596, P: 133-137