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Showing 1–10 of 10 results
Advanced filters: Author: Marcus Buschbeck Clear advanced filters

  • Azacitidine (AZA) treatment is used for patients with myelodysplasias that cannot undergo bone marrow transplantation; however, AZA treatment is only partially effective. Here the authors show synergy of AZA with compounds inhibiting the chromatin regulators CBP and p300, which is mediated by the RNA-dependent functions of AZA affecting protein translation.

    • Jeannine Diesch
    • Marguerite-Marie Le Pannérer
    • Marcus Buschbeck
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • DNA transactions promote torsional constraints that pose inherent risks to genome integrity. Here the authors identify the macro-histone splice variant macroH2A1.1 as an epigenetic modulator of topoisomerase 1-associated genome maintenance. MacroH2A1.1 expression determines sensitivity to TOP1 poisons and may present a cancer vulnerability.

    • Tae-Hee Lee
    • Colina X. Qiao
    • Philipp Oberdoerffer
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • MacroH2A histone variants originated before the split of fungi and animals. ADP-ribose binding is an ancestral feature of their macrodomains and is linked to the compartmental regulation of NAD metabolism. This function was selected for during the evolution of metazoans.

    • Iva Guberovic
    • Sarah Hurtado-Bagès
    • Marcus Buschbeck
    Research
    Nature Structural & Molecular Biology
    Volume: 28, P: 1009-1019

  • Core histone proteins are deposited on chromatin during DNA replication, whereas their replication-independent variants are deposited throughout the cell cycle by specific chaperones and chromatin remodellers. This dynamic deposition of histone variants has important roles in cell fate specification and has been implicated in development and tumorigenesis.

    • Marcus Buschbeck
    • Sandra B. Hake
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 18, P: 299-314

  • The role of genome folding in the heritability and evolvability of structural variations is not well understood. Here the authors investigate the impact of the three-dimensional genome topology of germ cells in the formation and transmission of gross structural genomic changes detected from comparing whole-genome sequences of 14 rodent species.

    • Lucía Álvarez-González
    • Frances Burden
    • Aurora Ruiz-Herrera
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • The interaction of non-immune and immune cells in the tumour microenvironment (TME) determines the quality of the immune attack on nascent tumour cells. A new study in melanoma cells shows that specific histone variants dampen the expression of cytokine genes in cancer-associated fibroblasts, leading to an immunosuppressive TME.

    • David Corujo
    • Marcus Buschbeck
    News & Views
    Nature Cell Biology
    Volume: 25, P: 1245-1246

  • Nucleosomes can be modified by replacing the core histones with variants, the most diverse of which is macroH2A. The localization of macroH2A variants in human male pluripotent cells indicates that this variant functions in repression of key developmental genes and is essential for zebrafish embryogenesis.

    • Marcus Buschbeck
    • Iris Uribesalgo
    • Luciano Di Croce
    Research
    Nature Structural & Molecular Biology
    Volume: 16, P: 1074-1079

  • The MYC proto-oncogene modulates transcription through binding to E-boxes. Di Croce and colleagues find that PAK-2-mediated phosphorylation confers a tumour-suppressive function to MYC, in which MYC cooperates with differentiation signals to positively modulate the transcription of genes targeted by retinoic acid, independently of E-boxes.

    • Iris Uribesalgo
    • Marcus Buschbeck
    • Luciano Di Croce
    Research
    Nature Cell Biology
    Volume: 13, P: 1443-1449