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Showing 1–10 of 10 results
Advanced filters: Author: Marcus Panning Clear advanced filters
  • Oral vaccines against Vibrio cholera have been critical for cholera management, but the production of more efficacious and cost-effective approaches is still needed. Here the authors deliver a bivalent VHH construct that binds to cholera toxin and show protection in a murine cholera model.

    • Marcus Petersson
    • Franz G. Zingl
    • Sandra Wingaard Thrane
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14
  • Human transplantation with allogeneic donor organs results in non-matching of MHC and differential presentation of T cell antigens. Here the authors show that in a lung transplanted SARS-CoV-2 infected patient T cell responses generated from the host may not be able to recognise infected cells within the graft and this may contribute to virus persistence.

    • Jonas Fuchs
    • Vivien Karl
    • Björn C. Frye
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13
  • Affinity-selection platforms are powerful tools in early drug discovery, but current technologies such as DNA-encoded libraries (DELs) are limited by synthesis complexity and incompatibility with nucleic acid binding targets. Here, the authors present a barcode-free self-encoded library (SEL) platform that enables direct screening of over half a million small molecules in a single experiment.

    • Edith van der Nol
    • Nils Alexander Haupt
    • Sebastian Pomplun
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12
  • varVAMP is open-source software for designing primers for tiled-amplicon sequencing and qPCR. It simplifies primer design for viral pathogens with high genomic variability by including sequence variations into primer sequences.

    • Jonas Fuchs
    • Johanna Kleine
    • Marcus Panning
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19
  • Antibodies against SARS-CoV-2 can be used to treat infections but there is a risk of driving viral resistance to antibodies. Here the authors characterise SARS-CoV-2 escape mutants from an immunocompromised patient treated with anti-SARS-CoV-2 antibodies using mouse protection studies and structural prediction.

    • Lena Jaki
    • Sebastian Weigang
    • Jonas Fuchs
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14
  • The A.27 SARS-CoV-2 lineage spread globally in 2021 but did not become dominant. Here, the authors show that A.27 shares some mutations in the spike gene that are present in variants of concern, but lacks the D614G mutation, indicating independent evolution of immune escape properties.

    • Tamara Kaleta
    • Lisa Kern
    • Jonas Fuchs
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13