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Showing 1–3 of 3 results
Advanced filters: Author: Marek Adamowicz Clear advanced filters

  • Adamowicz et al. report that toxic PARP1 activity, induced by ataxia-associated mutations in XRCC1, impairs the recovery of global transcription during DNA base excision repair by promoting aberrant recruitment and activity of the histone ubiquitin protease USP3.

    • Marek Adamowicz
    • Richard Hailstone
    • Keith W. Caldecott
    ResearchOpen Access
    Nature Cell Biology
    Volume: 23, P: 1287-1298

  • Long non-coding RNAs transcribed at DNA damaged sites can play part in DNA damage response. Here the authors reveal that damaged induced lncRNAs can form DNA:RNA hybrids at resected DNA-ends. These hybrids are involved in recruiting HR-mediated repair machinery which, in turn, controls their level at DSBs.

    • Giuseppina D’Alessandro
    • Donna Rose Whelan
    • Fabrizio d’Adda di Fagagna
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-17

  • Assays in both C. elegans and human cells show that Notch interacts with ATM kinase to inhibit the DNA-damage response and that Notch activity is inversely correlated with ATM activation in breast cancer cells.

    • Jelena Vermezovic
    • Marek Adamowicz
    • Fabrizio d'Adda di Fagagna
    Research
    Nature Structural & Molecular Biology
    Volume: 22, P: 417-424