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Showing 1–2 of 2 results
Advanced filters: Author: Margaret L. Clapp Sullivan Clear advanced filters
  • In a phase 2 trial of adults with neurofibromatosis type 1 and inoperable/growing plexiform neurofibromas, treatment with the MEK inhibitor selumetinib resulted in an objective response rate of 63.6% and improvement in other patient outcomes, with additional biopsy-based data providing further information on drug activity.

    • Andrea M. Gross
    • Geraldine O’Sullivan Coyne
    • Brigitte C. Widemann
    Research
    Nature Medicine
    Volume: 31, P: 105-115
  • The authors address the central criticism of latent variable models in behavioural science, which is that a wide range of causal models may account for the observed data (the factor indeterminacy problem). They review how researchers have recently started using genome-wide data to provide a source of additional information to help to overcome the factor indeterminacy problem by decomposing the genome into a set of uncorrelated units.

    • Margaret L. Clapp Sullivan
    • Ted Schwaba
    • Elliot M. Tucker-Drob
    Reviews
    Nature Human Behaviour
    Volume: 8, P: 205-218