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Communications Biology (1)

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Lipolysis-derived fatty acids are needed for homeostatic control of sterol element-binding protein-1c driven hepatic lipogenesis

Fatty acids released by ATGL in adipose tissue inhibit post-translational activation of SREBP1c in the liver. We propose that this ATGL/SREBP-1c axis adds an additional layer of coordination between lipolysis and lipogenesis.

Paola Peña de la Sancha
Beatrix Irene Wieser
Paul Willibald Vesely
ResearchOpen Access09 Apr 2025
Communications Biology

Volume: 8, P: 1-14

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Lipolysis-derived fatty acids are needed for homeostatic control of sterol element-binding protein-1c driven hepatic lipogenesis

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