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Showing 1–9 of 9 results
Advanced filters: Author: Margarida Cardoso-Moreira Clear advanced filters

  • Analysis of RNA-seq datasets from seven organs across seven species generates an alternative splicing (AS) atlas and shows that AS events provide functional gene diversification through generation of tissue- and time-specific transcript isoforms.

    • Pavel V. Mazin
    • Philipp Khaitovich
    • Henrik Kaessmann
    ResearchOpen Access
    Nature Genetics
    Volume: 53, P: 925-934

  • A transcriptome dataset from seven organs and seven mammalian species throughout development is used to analyse the expression of long noncoding RNAs in tissues within and between species, and at different stages of organ development.

    • Ioannis Sarropoulos
    • Ray Marin
    • Henrik Kaessmann
    Research
    Nature
    Volume: 571, P: 510-514

  • Birds have evolved a unique sex chromosome dosage compensation mechanism involving the male-biased microRNA (miR-2954), which is essential for male survival by regulating the expression of dosage-sensitive Z-linked genes.

    • Amir Fallahshahroudi
    • Sara Yousefi Taemeh
    • Henrik Kaessmann
    ResearchOpen Access
    Nature
    Volume: 645, P: 148-157

  • Single-nucleus RNA-sequencing data from the cerebellum of human, mouse and opossum is used to analyse the developmental dynamics of cell types and states in mammalian cerebellum and provide evolutionary insights.

    • Mari Sepp
    • Kevin Leiss
    • Henrik Kaessmann
    ResearchOpen Access
    Nature
    Volume: 625, P: 788-796

  • An analysis using ribosome-profiling and matched RNA-sequencing data for three organs across five mammalian species and a bird enables the comparison of translatomes and transcriptomes, revealing patterns of co-evolution of these two expression layers.

    • Zhong-Yi Wang
    • Evgeny Leushkin
    • Henrik Kaessmann
    Research
    Nature
    Volume: 588, P: 642-647

  • Phosphorylation of the essential myosin light chain (ELC) influence actin-myosin crossbridge cycling in the heart. Here, the authors show upregulated ELC-phosphorylation in systolic heart failure and identify NIMArelated kinase 9 to bind to ELC mediating its calcium-dependent phosphorylation.

    • Marion Müller
    • Rose Eghbalian
    • Benjamin Meder
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18

  • Evolutionary analyses of single-nucleus transcriptome data for testes from 11 species are reported, illuminating the molecular evolution of spermatogenesis and associated forces, and providing a resource for investigating the testis across mammals.

    • Florent Murat
    • Noe Mbengue
    • Henrik Kaessmann
    ResearchOpen Access
    Nature
    Volume: 613, P: 308-316

  • The transcriptomes of seven major organs across developmental stages from several mammalian species are used for comparative analyses of gene expression and evolution across organ development.

    • Margarida Cardoso-Moreira
    • Jean Halbert
    • Henrik Kaessmann
    Research
    Nature
    Volume: 571, P: 505-509

  • Fruit flies gain valuable information about their environment by sensing chemicals. Here, Arguello et al. show strong signals of recent selection on the chemosensory system of the fruit fly Drosophila melanogaster, consistent with the adaptation of populations to their local chemical environment.

    • J. Roman Arguello
    • Margarida Cardoso-Moreira
    • Richard Benton
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12