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Targeting cell surface GRP78-CD44v interaction suppresses cell migration in triple-negative breast cancer cells

Chun-Chih Tseng
Pu Zhang
Amy S. Lee
ResearchOpen Access21 Dec 2025
Scientific Reports

Volume: 16, P: 1-11
Dietary glutamine supplementation suppresses epigenetically-activated oncogenic pathways to inhibit melanoma tumour growth

The availability of nutrients within the tumour microenvironment can influence tumour growth. Here, the authors find that, in a melanoma mouse model, mice fed a high glutamine diet have reduced tumour growth, increased sensitivity to Braf inhibitors and elevated a-ketoglutarate levels.

Mari B. Ishak Gabra
Ying Yang
Mei Kong
ResearchOpen Access03 Jul 2020
Nature Communications

Volume: 11, P: 1-15
MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1

Pancreatic ductal adenocarcinoma must adapt to a nutrient-poor microenvironment. Here, the authors show that miR-135 accumulates in response to glutamine deprivation and inhibits aerobic glycolysis by targeting phosphofructokinase-1, thereby redirecting glucose carbon to the TCA cycle and allowing pancreatic cancer cells survival.

Ying Yang
Mari B. Ishak Gabra
Mei Kong
ResearchOpen Access18 Feb 2019
Nature Communications

Volume: 10, P: 1-15
α-Ketoglutarate attenuates Wnt signaling and drives differentiation in colorectal cancer

Tran et al. show that environmental glutamine restriction promotes Wnt signaling and intestinal tumorigenesis, whereas supplementation of the metabolite α-ketoglutarate has the reverse effect, reducing tumor growth and extending survival.

Thai Q. Tran
Eric A. Hanse
Mei Kong
Research20 Mar 2020
Nature Cancer

Volume: 1, P: 345-358
Transcriptional diversity and bioenergetic shift in human breast cancer metastasis revealed by single-cell RNA sequencing

Davis et al. demonstrate heterogeneous and distinct transcriptome programs in breast cancer micrometastasis associated with upregulated mitochondrial oxidative phosphorylation.

Ryan T. Davis
Kerrigan Blake
Devon A. Lawson
Research06 Mar 2020
Nature Cell Biology

Volume: 22, P: 310-320
IKKβ activates p53 to promote cancer cell adaptation to glutamine deprivation

Mari B. Ishak Gabra
Ying Yang
Mei Kong
ResearchOpen Access26 Nov 2018
Oncogenesis

Volume: 7, P: 1-12

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Targeting cell surface GRP78-CD44v interaction suppresses cell migration in triple-negative breast cancer cells

Dietary glutamine supplementation suppresses epigenetically-activated oncogenic pathways to inhibit melanoma tumour growth

MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1

α-Ketoglutarate attenuates Wnt signaling and drives differentiation in colorectal cancer

Transcriptional diversity and bioenergetic shift in human breast cancer metastasis revealed by single-cell RNA sequencing

IKKβ activates p53 to promote cancer cell adaptation to glutamine deprivation

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