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Showing 1–5 of 5 results

Advanced filters: Author: Maria C. Scali Clear advanced filters

siRNA screen identifies QPCT as a druggable target for Huntington's disease

An siRNA screen for genes that suppress mutant huntingtin toxicity in both mammalian cells and Drosophila identifies glutaminyl cyclase (QPCT). Newly generated small-molecule inhibitors further identify QPCT as a druggable target for Huntington′s disease.

Maria Jimenez-Sanchez
Wun Lam
David C Rubinsztein
Research06 Apr 2015
Nature Chemical Biology

Volume: 11, P: 347-354
New orphan disease therapies from the proteome of industrial plasma processing waste- a treatment for aceruloplasminemia

Proteomics of waste intermediates from industrial plasma fractionation samples revealed new candidate therapeutic proteins such as ceruloplasmin, which reverted central nervous system and peripheral deficits in ceruloplasmin-deficient mice.

Alan Zanardi
Ilaria Nardini
Massimo Alessio
ResearchOpen Access30 Jan 2024
Communications Biology

Volume: 7, P: 1-17
Salivary lactate and 8-isoprostaglandin F_2α as potential non-invasive biomarkers for monitoring heart failure: a pilot study

Silvia Ghimenti
Tommaso Lomonaco
Roger Fuoco
ResearchOpen Access04 May 2020
Scientific Reports

Volume: 10, P: 1-11
In vitro and in vivo efficacy, toxicity, bio-distribution and resistance selection of a novel antibacterial drug candidate

Jlenia Brunetti
Chiara Falciani
Alessandro Pini
ResearchOpen Access12 May 2016
Scientific Reports

Volume: 6, P: 1-12
Morph-specific protein patterns in the femoral gland secretions of a colour polymorphic lizard

Marco Mangiacotti
Marco Fumagalli
Roberto Sacchi
ResearchOpen Access10 Jun 2019
Scientific Reports

Volume: 9, P: 1-12