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Showing 1–9 of 9 results
Advanced filters: Author: Maria Casanova-Acebes Clear advanced filters

  • Macrophages can differentiate to perform homeostatic tissue-specific functions. Here the authors show that RXR signalling is critical for large peritoneal macrophage (LPM) expansion during neonatal life and LPM lipid metabolism and survival during adult homeostasis, and that ovarian cancer growth relies on RXR-dependent LPMs. 

    • María Casanova-Acebes
    • María Piedad Menéndez-Gutiérrez
    • Mercedes Ricote
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

  • Early dissemination of cancer cells has been reported to occur in certain breast cancer models. Here the authors show that intra-epithelial macrophages in the early pre-cancer lesions drive early cancer cell dissemination through Wnt-1 secretion and that such events impact the later development of metastasis.

    • Nina Linde
    • Maria Casanova-Acebes
    • Julio A. Aguirre-Ghiso
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14

  • In non-small cell lung cancer, the presence of monocyte-derived macrophages inversely correlates with the presence of NK cells. Merad and colleagues propose that when monocytes phagocytose tumor debris they express TREM2, become pro-tumorigenic, and suppress NK cell recruitment and activation in tumors.

    • Matthew D. Park
    • Ivan Reyes-Torres
    • Miriam Merad
    Research
    Nature Immunology
    Volume: 24, P: 792-801

  • Senescence of hematopoietic progenitor cells, enforced by the BRAFV600E mutation, underlies the development of Langerhans cell histiocytosis and could be a new target for drug development and therapy of this disease in patients.

    • Camille Bigenwald
    • Jessica Le Berichel
    • Miriam Merad
    Research
    Nature Medicine
    Volume: 27, P: 851-861

  • Liver X receptors (LXRs) are transcription factors that respond to sterols. Castrillo and colleagues identify a unique requirement for LXRα in the development of splenic marginal zone macrophages and their antibody responses to blood-borne antigen.

    • Noelia A-Gonzalez
    • Jose A Guillen
    • Antonio Castrillo
    Research
    Nature Immunology
    Volume: 14, P: 831-839

  • Genetic polymorphisms affect expression of the atypical chemokine receptor ACKR1 (Duffy) on nucleated erythrocyte precursors. Rot and colleagues show that loss of its expression alters hematopoiesis, yielding a distinct neutrophil population that rapidly exits the bloodstream to give an apparent ‘neutropenia’ phenotype.

    • Johan Duchene
    • Igor Novitzky-Basso
    • Antal Rot
    Research
    Nature Immunology
    Volume: 18, P: 753-761

  • This Comment article from the Precision Immunology Institute at the Icahn School of Medicine (PrIISM), New York, describes their efforts to provide critical reviews of COVID-19 articles posted daily on the preprint servers bioRxiv and medRxiv.

    • Nicolas Vabret
    • Robert Samstein
    • Uri Laserson
    Comments & Opinion
    Nature Reviews Immunology
    Volume: 20, P: 338