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Advanced filters: Author: Maria Goralski Clear advanced filters

The antitumor toxin CD437 is a direct inhibitor of DNA polymerase α

A forward-genetic screen revealed that the mutations in DNA polymerase α (POLA1) are resistant to the effects of CD437. The direct interaction of CD437 and POLA1 blocks DNA replication and promotes cancer cell death.

Ting Han
Maria Goralski
Deepak Nijhawan
Research16 May 2016
Nature Chemical Biology

Volume: 12, P: 511-515
Biomarkers for RBM39 degradation in acute myeloid leukemia

David Hsiehchen
Maria Goralski
Deepak Nijhawan
Research10 Feb 2020
Leukemia

Volume: 34, P: 1924-1928

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The antitumor toxin CD437 is a direct inhibitor of DNA polymerase α

Biomarkers for RBM39 degradation in acute myeloid leukemia

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