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Stem cells

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Perivascular niche cells sense thrombocytopenia and activate hematopoietic stem cells in an IL-1 dependent manner

Hematopoietic stem cells (HSCs) replenish blood cells. Here, Luis et al., identify a feedback mechanism by which IL-1 secreted by activated platelets signals through niche Lepr+ cells to activate HSCs and restore platelet homeostasis.

Tiago C. Luis
Nikolaos Barkas
Sten Eirik W. Jacobsen
ResearchOpen Access28 Sept 2023
Nature Communications

Volume: 14, P: 1-18

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Perivascular niche cells sense thrombocytopenia and activate hematopoietic stem cells in an IL-1 dependent manner

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