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Showing 1–3 of 3 results
Advanced filters: Author: Maria L. Sandoval-Romero Clear advanced filters

  • Natural killer T cells (NKT cells) recognize lipid antigens presented by CD1d. Zajonc and Rossjohn and their colleagues describe molecular interactions between type II NKT cell antigen receptors and CD1d-ligand complexes, which demonstrate distinct modes of recognition used by the receptors.

    • Onisha Patel
    • Daniel G Pellicci
    • Jamie Rossjohn
    Research
    Nature Immunology
    Volume: 13, P: 857-863

  • T-cell receptors expressed on mucosal-associated invariant T cells function in a similar manner to innate immune receptors by recognizing small molecules such as microbial metabolites. Here, the authors report structures of this receptor in complex with vitamin B metabolites presented by the MHC-like protein MR1.

    • Onisha Patel
    • Lars Kjer-Nielsen
    • Jamie Rossjohn
    Research
    Nature Communications
    Volume: 4, P: 1-9

  • CD1a presents a broad repertoire of lipid-based antigens. Rossjohn and colleagues show that the TCR docks over CD1a in a manner that precludes contact with permissive antigens, while nonpermissive antigens disrupt the TCR-CD1a contact.

    • Richard W Birkinshaw
    • Daniel G Pellicci
    • Jamie Rossjohn
    Research
    Nature Immunology
    Volume: 16, P: 258-266