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Showing 1–4 of 4 results
Advanced filters: Author: Maria Lukarska Clear advanced filters

  • Structural and biochemical studies of influenza virus RNA-dependent RNA polymerase (FluPol) in complex with transcribing host RNA polymerase II reveal the molecular mechanisms of RNA cap snatching by FluPol.

    • Alexander Helmut Rotsch
    • Delong Li
    • Patrick Cramer
    ResearchOpen Access
    Nature
    P: 1-8

  • A COVID-19 test implemented in an automated microfluidic device and leveraging isothermal RNA amplification followed by T7 transcription and Cas13-mediated cleavage of a quenched fluorophore rapidly detects SARS-CoV-2 RNA in saliva samples.

    • Sita S. Chandrasekaran
    • Shreeya Agrawal
    • Patrick D. Hsu
    Research
    Nature Biomedical Engineering
    Volume: 6, P: 944-956

  • Proteins evolve through the modular rearrangement of domains. Here the authors introduce MISER, a minimization by iterative size-exclusion and recombination method to make all possible deletions of a protein, uncovering functions for Cas9 domains involved in DNA binding.

    • Arik Shams
    • Sean A. Higgins
    • David F. Savage
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • The crystal structure of bat influenza A polymerase bound to a serine-5 phosphorylated peptide mimic from the C-terminal domain of cellular RNA polymerase II shows how the two polymerases are directly coupled and suggests that the interaction site could be targeted for antiviral drug development.

    • Maria Lukarska
    • Guillaume Fournier
    • Stephen Cusack
    Research
    Nature
    Volume: 541, P: 117-121