Recent studies suggest that mechanisms ofde novo lumen formation in different systems — such as the zebrafish vasculature, C. elegans excretory cells, the D. melanogastertrachea and three-dimensional cultures of endothelial and MDCK cells — share some common features. They all involve expansion of the apical plasma membrane, vesicle transport and regulation of the microtubule and actin cytoskeletons.
- Sara Sigurbjörnsdóttir
- Renjith Mathew
- Maria Leptin
