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Showing 1–5 of 5 results
Advanced filters: Author: Maria Shvedunova Clear advanced filters

  • After loss of MSL2, a class of dosage-sensitive genes transitions from biallelic to monoallelic expression, whereby one allele remains active, retaining active histone modifications and transcription factor binding, and the other allele is silenced, exhibiting loss of promoter–enhancer contacts and the acquisition of DNA methylation.

    • Yidan Sun
    • Meike Wiese
    • Asifa Akhtar
    ResearchOpen Access
    Nature
    Volume: 624, P: 173-181

  • Misregulation of chromatin has been linked to many conditions, including obesity, but the details remain unclear. Here the authors identify the H4 lysine 16 acetyltransferase MOF as a master regulator of glucose metabolism that is required for normal glucose uptake and fat storage.

    • Cecilia Pessoa Rodrigues
    • Aindrila Chatterjee
    • Asifa Akhtar
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-21

  • Comprehensive characterisation of RNA-protein interactions requires different levels of resolution. Here, the authors present an integrated mass spectrometry-based approach that allows them to define the Drosophila RNA-protein interactome from the level of multisubunit complexes down to the RNA-binding amino acid.

    • Amol Panhale
    • Florian M. Richter
    • Asifa Akhtar
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-22

  • Lysine acetyltransferases and lysine deacetylases regulate gene expression and protein function by controlling acetylation and deacetylation of histones and diverse non-histone proteins. The activity of lysine acetyltransferases and lysine deacetylases is regulated by cellular metabolic states, offering the potential for therapeutic modulation through dietary and pharmacological interventions.

    • Maria Shvedunova
    • Asifa Akhtar
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 23, P: 329-349