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Precision-guided therapy in H3K27-altered diffuse midline glioma

H3K27-altered diffuse midline gliomas are a highly aggressive form of paediatric brain cancer. Here, the authors present molecular profiling of 68 patients, and show the efficacy of precision-guided therapy based on this profiling.

Campbell J. L. McKay
Chelsea Mayoh
Dong-Anh Khuong-Quang
ResearchOpen Access19 May 2026
Nature Communications

P: 1-11
Dual targeting of polyamine synthesis and uptake in diffuse intrinsic pontine gliomas

Diffuse intrinsic pontine glioma (DIPG) is an almost incurable malignant childhood brain tumor. Here, the authors show that the polyamine synthetic pathway is activated in DIPG and that the dual targeting of polyamine synthesis and uptake results in prolonged survival in animal models.

Aaminah Khan
Laura D. Gamble
David S. Ziegler
ResearchOpen Access12 Feb 2021
Nature Communications

Volume: 12, P: 1-13
RNA N6-methyladenosine (m6A) regulates cell cycle progression in diffuse midline glioma (DMG) and confers sensitivity to FTO inhibition

Samuel E. Ross
Holly Holliday
Marcel E. Dinger
ResearchOpen Access26 Mar 2026
Cell Death & Disease

Volume: 17, P: 1-14
Identification of an optimal prolactin threshold to determine prolactinoma size using receiver operating characteristic analysis

Bianca M. Leca
Maria Mytilinaiou
Georgios K. Dimitriadis
ResearchOpen Access07 May 2021
Scientific Reports

Volume: 11, P: 1-7
Brief Report: Potent clinical and radiological response to larotrectinib in TRK fusion-driven high-grade glioma

David S. Ziegler
Marie Wong
Michelle Haber
ResearchOpen Access17 Sept 2018
British Journal of Cancer

Volume: 119, P: 693-696